Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart

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Authors	OLEJNÍČKOVÁ Veronika RONZHINA Marina JANOUŠEK Oto KOLÁŘOVÁ Jana FIALOVÁ Kateřina PROVAZNÍK Ivo NOVÁKOVÁ Marie
Year of publication	2015
Type	Article in Proceedings
Conference	Computing in Cardiology, 2015.
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	heart; di-4-ANNEPS; electrogram
Description	Voltage sensitive dye di-4-ANEPPS is widely used in studies of cardiac electrophysiology. Although reduction of cardiac impulse propagation and prolongation of RR interval in the presence of di-4-ANEPPS is known, the effect on impulse conduction through AV node has not been studied yet. In this study the quantification of di-4-ANEPPS impact on duration of impulse conduction through AV node and ventricles in isolated rabbit hearts was done. It can be concluded that voltage sensitive dye di-4-ANEPPS leads to prolongation of cardiac impulse conduction through the ventricles. Conduction through AV node is impaired only slightly.
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