Haplotype analysis of interleukin-6 gene promoter polymorphisms in patients with chronic periodontitis and diabetes mellitus

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Authors	VALOVÁ Simona BOŘILOVÁ LINHARTOVÁ Petra KAŇKOVÁ Kateřina POSKEROVÁ Hana VOKURKA Jan FASSMANN Antonín IZAKOVIČOVÁ HOLLÁ Lydie
Year of publication	2015
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The aim of our study was to investigate the association of single nucleotide polymorphisms at positions -174G/C (rs1800795), -572G/C (rs1800796) and -597G/A (rs1800797), and their combinations (haplotypes) in patients with CP, type 1 DM (T1DM) and type 2 DM (T2DM) in comparison with healthy controls. Our results indicate that different IL-6 promoter haplotypes can affect the risk for CP and DM development. However, the individual IL-6 gene promoter polymorphisms do not act independently and may affect each other.
Related projects:	Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu Centrum orofaciálního vývoje a regenerace Etiopatogeneze, diagnostika a léčba vybraných patologických stavů v dutině ústní