Identification of molecules mediating c-myb-dependent chemoresistance of colorectal carcinoma cells

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Authors

PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia ŠMARDA Jan

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Colorectal carcinoma (CRC) is the third most common cancer worldwide. High c-Myb expression is frequently associated with a variety of immature cell lineages, and it decreases as cells differentiate. Patients with colorectal carcinomas exhibiting upregulated c-Myb expression have poor prognosis. The aim of our study was to clarify the role of c-Myb in control of the cell death/survival of CRC cells treated with cytotoxic agents. We showed that c-Myb reduced sensitivity of CRC cells to the cytotoxic agents. We tested the levels of ROS and expression/activity of key components of several signalling pathways to identify downstream effectors mediating the effect of c-Myb on cell viability. We identified the enhanced levels of (a) ROS-generating NADPH oxidase (NOX), (b) the phosphorylated MAPKp38, and (c) JNK/c-Jun kinases upon c-Myb overexpression. In this work we documented for the first time that the prosurvival effect of c-Myb is associated with NOX1-dependent regulation of ROS and we discuss the role of c-Myb-ROS axis in activation of MAPKp38 and c-Jun kinases.
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