Analysis of B-Cell Subpopulations in Monoclonal Gammopathies

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Authors

VŠIANSKÁ Pavla ŘÍHOVÁ Lucie VARMUŽOVÁ Tamara SUSKÁ Renata KRYUKOV Fedor MIKULÁŠOVÁ Aneta KUPSKÁ Renata PENKA Miroslav POUR Luděk ADAM Zdeněk HÁJEK Roman

Year of publication 2015
Type Article in Periodical
Magazine / Source Clinical Lymphoma Myeloma & Leukemia
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.clml.2014.12.003
Field Oncology and hematology
Keywords B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell
Description To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations.
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