Analysis of B-Cell Subpopulations in Monoclonal Gammopathies

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Authors	VŠIANSKÁ Pavla ŘÍHOVÁ Lucie VARMUŽOVÁ Tamara SUSKÁ Renata KRYUKOV Fedor MIKULÁŠOVÁ Aneta KUPSKÁ Renata PENKA Miroslav POUR Luděk ADAM Zdeněk HÁJEK Roman
Year of publication	2015
Type	Article in Periodical
Magazine / Source	Clinical Lymphoma Myeloma & Leukemia
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1016/j.clml.2014.12.003
Field	Oncology and hematology
Keywords	B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell
Description	To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations.
Related projects:	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií