Comparison of capillary electrophoresis and isothermal titration calorimetry for determination of the binding constant

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Authors

MICHALCOVÁ Lenka NEVÍDALOVÁ Hana GLATZ Zdeněk

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The binding constant is commonly used to describe the strength of binding between ligands (drugs) and protein. The strength of the interaction has a significant effect on the biological activity of the drug, and knowledge of the nature and extent of drug-protein binding can help us to understand the pharmacokinetics and pharmacodynamics of a drug. The binding constant may be determined by various methods. The main objective of the study was to compare the results of capillary electrophoresis and isotermal titration calorimetry.
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