Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects

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Authors

KRAJČOVIČOVÁ Lenka MAREČEK Radek MIKL Michal REKTOROVÁ Irena

Year of publication 2014
Type Article in Periodical
Magazine / Source CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
Doi http://dx.doi.org/10.1007/s11910-014-0491-3
Field Neurology, neurosurgery, neurosciences
Keywords Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment
Description The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.
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