STUDY OF PROTEIN AND DRUG INTERACTIONS BY CAPILLARY ELETROFORESIS – MASS SPECTROMETRY
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Proceedings |
| Conference | 11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014 |
| MU Faculty or unit | |
| Citation | |
| Web | CECE 2014 |
| Field | Biochemistry |
| Keywords | capillary electrophoresis - mass spectrometry; interaction drug - HSA |
| Description | Capillary electrophoresis hyphenated to mass spectrometry in frontal analysis mode (CE/FA-MS) was used to study the affinity between glimepiride and human serum albumin. Utilizing of both external and internal calibration methods for quantification of free drug concentration and subsequent determining of binding constants is presented in this contribution. |
| Related projects: |