Determination of binding constants of selected sulfonylureas drugs

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Authors

MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The strength of the interaction has a significant effect on biological activity of the drug. Various sulfonylureas (antidiabetic drugs) may induce hypoglycemia as a result of excesses in insulin production and release. Therefore, it is important to understand in detail the pharmacokinetics and pharmacodynamics of these drugs. The main objectives of this study were to determine the binding constants of the selected sulfonylurea drug (tolbutamide, chlorpropamide) with HSA using capillary electrophoresis – in physiological conditions.
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