Determination of binding constant of 1st generation antidiabetic drug with human serum albumin

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Authors	MICHALCOVÁ Lenka GLATZ Zdeněk
Year of publication	2014
Type	Article in Proceedings
Conference	11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014
MU Faculty or unit	Faculty of Science
Citation
Web	Oficiální stránky konference
Field	Biochemistry
Keywords	capillary electrophoresis - frontal analysis; 1st generation anitiabetic drugs; HSA
Description	The capillary electrophoresis fontal analysis (CE-FA) was used to study the affinities between selected 1st generation antidiabetic drugs (tolbutamide, chlorpropamide) and human serum albumin (HSA). The binding constant (Kb) was measured under physiological conditions. The log Kb values obtained by means of CE-FA have a good repeatability (RSD < 3%).
Related projects:	Centrum pokročilých bioanalytických technologií