Mysterious Role of H3K56ac in Embryonic Stem Cells

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Authors

STEJSKAL Stanislav TESAŘOVÁ Lenka KRONTORÁD KOUTNÁ Irena

Year of publication 2014
Type Article in Periodical
Magazine / Source Folia biologica
MU Faculty or unit

Faculty of Informatics

Citation
Field Genetics and molecular biology
Keywords H3K56ac;p300;CBP; pluripotency; chromatin
Description Posttranslational modifications of histones belong to epigenetic mechanisms that regulate gene expression by chromatin structure changes. Generally, histone acetylation reduces its positive charge and consequently weakens the stability of the nucleosome. Acetylation of lysine 56 on histone H3 is implicated in the processes associated with loosened chromatin structure. H3K56ac is a mark for histones with high nucleosome turnover in the nuclear processes such as gene transcription, DNA replication and reparation in yeasts. During evolution, the main H3K56ac regulatory pathway was lost and the level of H3K56ac remained very low in mammalian cells. Moreover, the function of this modification still re- mains unclear. In this minireview, we summarize the recent knowledge of the ambiguous role of H3K56ac in mammalian embryonic stem cells.
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