The role of c-Myb in oxidative stress: new strategies of anticancer therapy of colorectal carcinomas?

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Authors

PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia ŠMARDA Jan

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Colorectal carcinoma is the third most common cancer in the world. c-Myb is transcription factor and its overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival of patients. The aim of this study is to decipher signaling events underpinning the c-Myb-induced chemoresistance of CRC cells. We showed that c-Myb is significantly involved in pro-survival signaling pathways. We described a novel c-Myb-p38?/JNK signal axis mediating increased resistance of CRC cells to cytotoxic agents and documented for the first time that the prosurvival role of c-Myb is associated with deregulation of reactive oxygen species (ROS). Moreover, we found positive correlation between levels of c-Myb, ROS and pAMPK kinase in CRC cells and we open new question on the role of c-Myb in metabolic precesses of CRC cells.
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