Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach
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| Year of publication | 2014 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | In this work, the concentration dependences of ethanol-induced inhibition/activation of ionic currents derived from experimental data were incorporated into the published models of rat and human ventricular cardiomyocyte with the aim to assess the share of ionic current components in ethanol-induced changes of AP configuration. Our results suggest that contribution of individual ionic current components to the effect of ethanol on AP repolarization in cardiac cell is strongly dependent on species differences in current densities. Because AP configuration in the human model shows only a small sensitivity to variations of IK1, the effect of ethanol-induced inhibition of IKr predominates implying prolongation of APD. This effect might contribute to the clinically observed prolongation of QTc interval in ECG under consumption of alcohol. |
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