Ethanol affects inward rectifier potassium current in rat atrial myocytes and in expressed human Kir2.3 channels

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter HOŠEK Jan ŠIMURDOVÁ Milena ŠIMURDA Jiří

Year of publication 2014
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description This is the first study demonstrating an effect of ethanol on the atrial IK1. The ethanol effect was apparent in a clinically relevant concentration and partly differed in rat atrial myocytes and in the expressed human Kir2.3 channels. The decline of IK1-inhibition during application of ethanol observed in rat atrial cells along with the following increase of IK1 in a part of these cells may be caused by an unknown mechanism which is not present in the human Kir2.3 channels expressed in CHO cells. Our experimental data suggest that ethanol-induced changes of the atrial IK1 might participate in the reported alterations of atrial electrophysiology under alcohol consumption.
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