Comparing the effects of cortical resection and vagus nerve stimulation in patients with nonlesional extratemporal epilepsy
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | EPILEPSY & BEHAVIOR |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.yebeh.2013.05.036 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Vagus nerve stimulation; Nonlesional extratemporal epilepsy; Cortical resection; Epilepsy surgery; Cost analysis |
| Description | The main purpose of this retrospective study was to compare the effects of resective surgery (RESgr-26 patients) and vagus nerve stimulation (VNSgr-35 patients) on seizure frequency (2 and 5 years after surgery) in patients with nonlesional extratemporal epilepsy (NLexTLE). We analyzed hospital admission costs directly associated with epilepsy (HACE) in both groups at the same follow-up. The decrease in seizure frequency from the preoperative levels, in both VNSgr and RESgr, was statistically significant (p < 0.001). The seizure frequency reduction did not differ significantly between the follow-up visits for either group (p = 0.221 at 2 years and 0.218 at 5 years). A significantly higher number of Engel I and Engel I + II patients were found in RESgr than in VNSgr at both follow-up visits (p = 0.04 and 0.007, respectively). Using McHugh classification, we did not find statistically significant differences between both groups at both follow-up visits. Hospital admission costs directly associated with epilepsy/patient/year in both RESgr and VNSgr dropped significantly at 2- and 5-year follow-up visit and this reduction was not statistically different between RESgr and VNSgr (p = 0.232). |
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