Proměnlivá tvář parkinsonské neurodegenerace

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Title in English The Changing Face of Parkinsonian Neurodegeneration
Authors

MENŠÍKOVÁ K. KAŇOVSKÝ P. KAISEROVÁ M. NESTRAŠIL I. BAREŠ Martin

Year of publication 2013
Type Article in Periodical
Magazine / Source CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords Parkinson’s disease; hereditary parkinsonism; neurodegenerative parkinsonism
Description Parkinson’s disease continues to be described as a relatively homogenous nosological entity, characterised by the presence of four cardinal signs – bradykinesia, rigidity, tremor and postural instability – with a variable presence of other motor and non-motor symptoms (cognitive, behavioral, vegetative etc.); its pathological basis being the continuous progression of brain alpha-synucleinopathy. It seemed that this clinical entity might be relatively easily diagnosed using the United Kingdom Parkinson’s D isease Brain Bank (UK- -PDBB) clinical diagnostic criteria that are based on the results of a retrospective clinical and pathological study. However, substantial opinion shift occurred as a result of the recent intensive field research. A distinction has arbitrarily been made between Dementia with Lewy bodies and Parkinson’s disease dementia. Several next mutations (PARK10–PARK13, PARK16–PARK18) encoding the manifestation of “sporadic“, late-onset and typical Parkinson’s disease have been added to the existing spectrum of familiar Parkinson’s disease. Therefore, the term “Parkinson’s disease” should be used for the “sporadic” form of the disease only. However, for the “definite” or “highly probable” level of diagnostic accuracy, the UK-PDBB criteria are less useful. The term “neurodegenerative Parkinsonism” would probably better reflect current level of diagnostic certainty referring to Parkinson’s disease.

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