Současný přístup k léčbě pacientů s metastatickým kolorektálním karcinomem
| Title in English | The current approach to the treatment of the patients with metastatic colorectal cancer |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | Colorectal cancer; Conversion therapy; Liver metastases; Targeted treatment |
| Description | Colorectal cancer is one of the most common malignant tumors. Despite the constant promotion of prevention remains around 20-30% of cases diagnosed in the metastatic stage and approximately 50-60% of patients developed the late dissemination. In 80-90% of them we can find already unresectable metastases. Although surgical treatment is basic modality of therapy, with using modern targeted therapy in combination with chemotherapy we can achieve long-term complete remission in the cases of advanced tumor and we can significantly prolonged the life of patients with this disease now. About 40-50% patients in advanced stages who underwent metastasectomy survives 5-years and 10-year survival rate is up to 25%. When administered systemic treatment median overall survival in these cases reaches around 24 months. |