Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin

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Authors	LEGARTOVÁ Soňa JUGOVÁ Alžběta STIXOVÁ Lenka KOZUBEK Stanislav FOJTOVÁ Miloslava ZDRÁHAL Zbyněk LOCHMANOVÁ Gabriela BÁRTOVÁ Eva
Year of publication	2013
Type	Article in Periodical
Magazine / Source	Biochemistry & Molecular Biology
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1016/j.biochi.2012.09.027
Field	Genetics and molecular biology
Keywords	Apoptosis; Histones; HP1; Epigenetics; Chromatin
Description	Apoptotic bodies are the most condensed form of chromatin. In general, chromatin structure and function are mostly dictated by histone post-translational modifications.HP1 mobility in apoptotic cells appeared to be unique because limited exchange after photobleaching was observed for other epigenetically important proteins, including GFP-JMJD2b histone demethylase (similar to 10% fluorescence recovery) or Polycomb group-related GFP-BMI1 protein (similar to 20% fluorescence recovery). These findings imply a novel fact that only certain subset of proteins in apoptotic bodies is dynamic.
Related projects:	CEITEC - Central European Institute of Technology Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii