Antitumour activities of sanguinarine and related alkaloids

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Authors

SLANINOVÁ Iva PĚNČÍKOVÁ Kristýna KANTOROVÁ Jana SLANINA Jiří TÁBORSKÁ Eva

Year of publication 2014
Type Article in Periodical
Magazine / Source Phytochemistry reviews
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s11101-013-9290-8
Field Genetics and molecular biology
Keywords Apoptosis; Anti-proliferative activity; Benzophenanthridine alkaloids; cancer; sanguinarine
Description Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy.
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