Global expression analysis of microRNAs in paired initial and relapsed glioblastoma

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Authors	ŠÁNA Jiří BEŠŠE Andrej LAKOMÝ Radek KŘEN Leoš KOSAŘOVÁ Zdeňka FADRUS Pavel ŠLAMPA Pavel SMRČKA Martin VYZULA Rostislav SLABÝ Ondřej
Year of publication	2013
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Glioblastoma multiforme (GBM) is the most commonly occurring primary brain tumour. Despite modern therapeutic approaches based on a radical resection, concomitant chemoradiotherapy with temozolomide and adjuvant chemotherapy, the median of overall survival is around 15 months from diagnosis. This infaust prognosis is mainly caused by GBM resistance to the indicated therapy. Therefore, it is very important to find new biomarkers, which will predict a clinical outcome of GBM patients who have undergone therapy with themozolomide. Recent studies show, that miRNAs could play an important role in chemo- and radioresistance of many tumours including GBM.
Related projects:	CEITEC - Central European Institute of Technology Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem