NOS3 polymorphisms are associated with progression of kidney and cardiovascular disease in type 2 diabetic patients
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| Year of publication | 2013 |
| Type | Conference abstract |
| Citation | |
| Description | We have previously identified association of 6 single nucleotide polymorphisms (SNP) with diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM) using multi-locus analysis in a case – control study comprising 419 type 2 diabetics and 228 healthy subjects genotyped for 45 SNPs in 20 candidate genes for DN. We identified SNPs in four genes – AGER (-429T>C and 2184A>G), EDN1 (8002G>A) and LTA (252A>G) on chromosome 6p and NOS3 (774C>T and 894G>T) on chromosome 7q - associated with DN in T2DM. In the present study we genotyped the same SNPs in the independent cohort of prospectively followed T2DM patients with aim to investigate their possible role in the progression of DN and development of morbidity and mortality associated with diabetes. |
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