Nalmefen v léčbě alkoholové závislosti
| Title in English | Nalmefene in Treatment of Alcohol Dependence |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | nalmefene; opioid system; alcohol dependence |
| Description | Nalmefene is a modulator of the endogenic opioid system acting as competitive antagonist at M and delta receptors and partial agonist at kappa receptors with predominant affinity to the M and kappa receptors. It belongs to agents suppressing well-documented changes in the brain opioid system associated with repeated effects of alcohol. This review provides an overview of both preclinical and clinical ev idence sug- gesting: a) an important role of the brain opioid system in development of alcoholism; b) a prospective use of nalmefene suppre ssing craving to reduce alcohol consumption and thus in pharmacotherapy of alcoholism. |
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