Polymorphisms in HLA-related genes and psoriasis heredity in patients with psoriasis

• Authors: VAŠKŮ Anna; BIENERTOVÁ VAŠKŮ Julie; IZAKOVIČOVÁ HOLLÁ Lydie; PÁVKOVÁ GOLDBERGOVÁ Monika; KOZÁČIKOVÁ Zuzana; ŠPLÍCHAL Zbyněk; VAŠKŮ Vladimír
• Year of publication: 2013
• Type: Article in Periodical
• Magazine / Source: International Journal of Dermatology
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/ijd.12213
• Field: Dermatovenerology
• Keywords: MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II REGION; HAPLOTYPE RECONSTRUCTION; MEIOTIC RECOMBINATION; POPULATION; SUSCEPTIBILITY; VULGARIS; ASSOCIATION; LOCUS
• Description: Background The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1333 a/b, TAP1637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF] [-238 G/A] and NcoI TNF) with characteristics of family history in patients with psoriasis vulgaris. Materials and methods A total of 201 Czech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in TAP1, TNF, and TNF genes (6p21.3) using the polymerase chain reaction-restriction fragment length polymorphism-based methodology. Results We observed significantly higher prevalence of Ile333Ile TAP1 allele in patients whose first-degree relatives had a positive family history of psoriasis (P-a=0.04). No differences related to family history of psoriasis were observed in HLA-DRB1*1501 polymorphism. As for the TNF (-238 G/A) polymorphism, a significant increase of the GG genotype was observed in patients, especially men with second- and third-degree relatives with psoriasis (P-g=0.008). Similarly, the B2B2 genotype of NcoI TNF polymorphism was more frequent in psoriatic patients, especially women, whose second- and third-degree relatives had psoriasis (P-g=0.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bcCB1A was different between not only men and women with psoriasis (P=0.007) but also between men and women without a family history of psoriasis (P=0.007). Conclusions Haplotype association of HLA gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.