Postavení repetitivní transkraniální magnetické stimulace v léčbě obsedantně-kompulzivní poruchy
| Title in English | Role of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | repetitive transcranial magnetic stimulation; rTMS; obsessive-compulsive disorder; OCD; stimulation; prefrontal cortex; orbitofrontal cortex; supplementary motor area |
| Attached files | |
| Description | Obsessive-compulsive disorder (OCD) is a severe mental disorder with often chronic course. The first option treatment strategies for OCD consist of high doses of serotonin acting antidepressants given over long periods of time and/ or cognitive-behavioral therapy. The most severe resistant forms of OCD may benefit except of ablative stereotactic neurosurgery from development of new types of focal neuromodulatory interventions like repetitive transcranial magnetic stimulation (rTMS). Up to now nine randomized controlled trials and three open trials assessing the safety and efficacy of rTMS in the treatment of OCD were published. The results of these studies show that neither low frequency nor high frequency rTMS focused on the prefrontal cortex is effective in the treatemnt of OCD. By contrast supplementary motor area and/or orbitofrontal cortex seem to be candicate regions for effective and well tolerated rTMS treatment of OCD. Future trials should aim at determining optimal demographic, clinical, stimulation and neurophysiological parameters correlated with good rTMS therapeutical outcome in the treatment of OCD. |
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