The role of microRNAs in mitochondria in cancer

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Authors

BIENERTOVÁ VAŠKŮ Julie ŠÁNA Jiří SLABÝ Ondřej

Year of publication 2013
Type Article in Periodical
Magazine / Source Cancer Letters
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.ncbi.nlm.nih.gov/pubmed/23665507
Doi http://dx.doi.org/10.1016/j.canlet.2013.05.001
Field Oncology and hematology
Keywords microRNA; mitochondria; Krebs cycle; apoptosis; mitophagy
Description Reprogramming of the energy metabolism in cancer cell presents progressive field of cancer research. This feature is associated mainly with the mitochondria, which is major energy source of eukaryotic cells. These organelles are essential to the cell homeostasis maintenance, play an important role in intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases including cancer. Recently, it was described that microRNAs (miRNAs) regulate important signaling pathways in mitochondria and many of these miRNAs are deregulated in various cancers. Here we summarize current knowledge about miRNAs involved in mitochondrial functioning with focus on cellular energy metabolism, apoptosis and mitophagy.
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