New Laser Desorption Sample Introduction Techniques for Inductively Coupled Plasma Mass Spectrometry

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Authors	PREISLER Jan FOLTYNOVÁ Pavla KANICKÝ Viktor TOMALOVÁ Iva VACULOVIČ Tomáš
Year of publication	2013
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	New techniques for determination of trace elements in submicroliter sample volumes, substrate-assisted laser desorption (SALD)1,2 and diode laser thermal vaporization (DLTV)3 inductively-coupled plasma mass spectrometry (ICP-MS) will be presented. In summary, the both SALD and DLTV ICP-MS are suitable for quantitative elemental analysis of low-volume samples (typically 100 – 500 nL) and represent an alternative to nebulizers. Ad-vantages are also easy archiving, transportation, prearrangement of calibration sets and high through-put due to minimization of memory effects. In addition, biological samples, such as metalloproteins or metal complexes can be analyzed in other detection modes (MALDI-MS or fluorescence) from the same sample, which can provide supplementary information, e.g. protein mass or identity.
Related projects:	Multidetection platform for microcolumn separation of proteins and peptides CEITEC - Central European Institute of Technology Nové strategie úpravy vzorků pro desorpční hmotnostní spektrometrii