Molekulární podstata Waldenströmovy makroglobulinemie
| Title in English | Molecular Basis of Waldenström Macroglobulinemia |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.linkos.cz/casopis-klinicka-onkologie/hledani-clanku/skupina/a/zobrazit/ids/4148/ |
| Field | Oncology and hematology |
| Keywords | Waldenström macroglobulinemia; IL-6; SDF-1; PLyS; PI3K/Akt; NF-kappaB; JAK/STAT |
| Attached files | |
| Description | Waldenström macroglobulinemia is a rare lymphoproliferative disease that is currently clasified into lymphomas with incidence of 3 cases per million. This disease comprises about 1–2% of hematological malignancies and is characterized by infiltration of malignant B cells into the bone marrow and presence of monoclonal immunoglobulin IgM in serum. WM is still an incurable disease with median survival of 5 years. Molecular basis of this disease remains unclear even though deletion of 6q, trisomy of chromosomes 4 and 8, deletion of 13q and increased expression of IL-6 seem to be typical for this disease. The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. This work aims to describe current knowledge about the molecular basis of this disease. |
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