Application on nanoparticles in desorption mass spectrometry

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Authors	PREISLER Jan TOMALOVÁ Iva CHANG Huan-Tsung
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Nanomaterials can serve as an alternative to matrix-assisted laser desorption/ionization (MALDI) matrix for the analysis of numerous analytes. This lecture will give a brief overview of nanoparticles used in the process called surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). Selected applications of gold nanoparticles (AuNPs) in SALDI MS will be presented to demostrate the potential and limitations of SALDI MS. AuNPs were used as s matrix for quantitative analysis of melamine in infant formula and grain powder and glutathione in grape leaves. Although quantitative analyses using SALDI MS without any internal standard is possible, use of internal of the internal standard for quantitative analysis is strongly advised. In the last example, SALDI-MS serves as a useful tool to examine the reaction process. In this case, AuNPs served as an efficient SALDI substrate to monitor redox reactions during nanoparticle formation process.
Related projects:	Analýza biomolekul hmotnostní spektrometrií s laserovou desorpcí/ionizací za účasti nanomateriálů CEITEC - Central European Institute of Technology