3rd ICCTI Workshop - MicroRNAs in Oncology

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Authors	SLABÝ Ondřej SVOBODA Marek HÉŽOVÁ Renata RÉDOVÁ Martina
Year of publication	2012
Type	Workshop
MU Faculty or unit	Central European Institute of Technology
Citation
Description	MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and developmnet. Changes in the expression profiles of miRNAs have been observed in a variety of human solidtumors and hametological malignancies. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNA as a novel class of therapeutic targets.