3rd ICCTI Workshop - MicroRNAs in Oncology

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Authors

SLABÝ Ondřej SVOBODA Marek HÉŽOVÁ Renata RÉDOVÁ Martina

Year of publication 2012
Type Workshop
MU Faculty or unit

Central European Institute of Technology

Citation
Description MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and developmnet. Changes in the expression profiles of miRNAs have been observed in a variety of human solidtumors and hametological malignancies. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNA as a novel class of therapeutic targets.

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