Význam dlouhých nekódujících RNA u nádorových onemocnění
| Title in English | The role of long non-coding RNAs in cancers |
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| Authors | |
| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The main part of eukaryotic genom is represented by DNA sequences that do not encode proteins. These sequences are transcribed according to developmental programm of particular organism or as an answer on external signals. It results in existence of large amount of long non-coding RNAs (lncRNAs). Whole-genome studies suppose that more than 3 300 lncRNAs exist. lncRNAs are defined as molecules of non-coding RNAs that are longer than 200 nucleotides. Up to now, only several lncRNAs have to been characterized, however, their regulatory potencial is evident. They play key roles in transcriptional as well as in post-transcriptional regulatory processes. They are often deregulated in different types of cancers and can affect the processes of malignant transformation. One of the class of lncRNAs are transcribed ultraconserved regionsa (T-UCR) that are highly homologic among human, rat and mouse genomes. Currently, 481 T-UCRs are known. They probably function as inhibitors of protein-coding genes and some non-coding RNAs including miRNAs. Recent studies proved that expression of T-UCR is deregulated in different types of cancers and correlates with clinical-pathological characteristics of patients. The results of our research are focused on the study of T-UCRs in CRC samples. |
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