Per3 VNTR polymorphism and chronic heart failure

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Authors

LIPKOVÁ Jolana BIENERTOVÁ VAŠKŮ Julie ŠPINAROVÁ Lenka BIENERT Petr HLAVNA Marián PÁVKOVÁ GOLDBERGOVÁ Monika PAŘENICA Jiří ŠPINAR Jindřich VAŠKŮ Anna

Year of publication 2014
Type Article in Periodical
Magazine / Source Biomedical Papers
MU Faculty or unit

Faculty of Medicine

Citation
Web http://biomed.papers.upol.cz/pdfs/bio/2014/01/12.pdf
Doi http://dx.doi.org/10.5507/bp.2012.069
Field Physiology
Keywords circadian clock; Per3; polymorphism; case-control study; chronic heart failure
Attached files
Description The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF). Methods. The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. Results. No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found. Conclusion. Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population.
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