Association of PSA level with thiols content in patients with prostate carcinoma

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Authors	MASAŘÍK Michal SOCHOR Jiří ZÍTKA Ondřej HYNEK David KŘÍŽKOVÁ Soňa STIBOROVÁ Marie ECKSCHLAGER Tomáš ADAM Vojtěch KIZEK René
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	To detect proste carcinoma, prostatic specific antigen (PSA) is mostly used. However, diagnostics of this tumour disease can become more precise using other types of molecules. In this study, we aimed at detennination of reduced (GSH) and oxidized (GSSG) glutathione, and its ratio, and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were petformed in 35 patients with prostate cancer at the age of 54 to 79 years with an average of 66 years and in 8 healthy subjects, who formed the control group. The correlation between PSA and GSH/GSSG reached R2=0.378. The value of PSA and metallothionein content was correlated with R2 = 0.589. However, there were observed large differences between the values of the ratio of GSH and GSSG, which were significantly (P<0.0 1) higher in the control group than in the group of patients with prostate cancer. Also, differences in content between metallothionein control group and a group of patients were highly significant (P<0.01).
Related projects:	CEITEC - Central European Institute of Technology