CHANGES IN SYSTOLIC BLOOD PRESSURE AND PULSE INTERVAL VARIABILITY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

• Authors: ZÁVODNÁ Eva; HONZÍKOVÁ Nataša; NOVÁKOVÁ Zuzana; HRSTKOVÁ Hana; BOTHOVÁ Pavla; BRÁZDOVÁ Ludmila; FIŠER Bohumil
• Year of publication: 2011
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Introduction: Polyneuropathy quite often accompanies diabetes mellitus and probably affects all organs. The aim of the study was to show differences in systolic blood pressure and heart rate variability in children with type 1 diabetes mellitus (T1DM). Methods: We examined 382 healthy (Co) children and adolescents (14.8 +- 2.6 years) and 34 patients with T1DM (15.0+- 3.2 years). We recorded systolic blood pressure (SBP) and pulse intervals (PI) beat-to-beat by non-invasive methods (Finapres) in all subjects for 5 min. The breathing was controlled by a metronome at a frequency of 0.33 Hz. The SBP and PI variability were determined as spectral power in the low frequency (LF) range (nSBPlf, nPIlf) and of respiratory (HF) range (nSBPhf, nPIhf) in normalised units, and in absolute values as well (vSBPlf, vPIlf, vSBPhf, vPIhf). Results: We did not find significant differences between controls and T1DM in SBP and PI variability LF range (nPIlf: Co=0.057 +- 0.031, T1DM=0.063 +- 0.027; nSBPlf: Co=0.046 +- 0.026, T1DM=0.046 +- 0.021; vPIlf: Co=15132 +- 14167, T1DM=16672 +- 16583 ms2/Hz; vSBPlf: Co=147 +- 119, T1DM=224 +- 242 mmHg2/Hz). However, there were significant differences in the HF range (nPIhf: Co=0.104 +- 0.064, T1DM=0.081 +- 0.056, p<0.05; nSBPhf: Co=0.058 +- 0.048, T1DM=0.035+-0.038, p<0.001; vPIhf: Co=30570+-39385, T1DM=17078+-16653 ms2/Hz, p<0.01; vSBPhf: Co=152+-145, T1DM=98+-63 mmHg2/Hz, p<0.05). Discussion: Decreased values of SBP and PI variability in children with T1DM in the high frequency region indicate early impairment of parasympathetic activity.