Přínos fenotypizace plazmocytů v diagnostice mnohočetného myelomu a monoklonální gamapatie nejasného významu

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Title in English	Plasma cells phenotypisation in diagnostics of multiple myeloma and monoclonal gammopathy of undetermined significance
Authors	KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana SUSKÁ Renata POUR Luděk ZAHRADOVÁ Lenka PENKA Miroslav HÁJEK Roman
Year of publication	2008
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The aim of this study was to analyse number of plasma cells (PCs) in diagnostics of monoclonal gammopathies (multiple myeloma, monoclonal gammopathy of undetermined significance) and to find parameter which can distinguish between MGUS and MM. Lower number of PCs was found in MGUS patients when compared with MM patients and these PCs can be separated into subpopulations including normal residual CD19+CD56- PCs and abnormal CD56+CD19- (alternatively CD56+CD19+ or CD56-CD19- in MM cases) PCs. Surface marker CD19 is a useful parameter for identification of normal residual PCs and this parameter can help also in differential diagnosis of monoclonal gammopathy. We would like to use this evaluation of PCs for detection of minimal residual disease and study of prognosis as well.
Related projects:	University Research Centre - Czech Myeloma Group